Photo of Wardle, Margaret

Margaret Wardle, PhD

Assistant Professor

Clinical

Pronouns: She/Her

Contact

Building & Room:

1050B BSB

Office Phone:

(312) 413-5564

About

The overall goal of my program of research is the development of more effective interventions for addiction.

I do this by focusing on how emotions are drive drug use, using both basic human laboratory studies and clinical trials.

I examine the basic effects of drugs on emotions by testing how small doses of drugs given in the laboratory change emotional functioning in healthy volunteers.

I also examine the long-term disruptions of emotional functioning that occur in addiction. My recent work has focused on deficits in positive emotion. Many individuals with addictions report difficulty experiencing pleasure or motivation for non-drug activities and rewards. This lack of enjoyment predicts difficulty with quitting. My current grant from the National Institute on Drug Abuse, “Targeting Anhedonia in Cocaine Use Disorder”, examines the neural mechanisms that may underlie these problems with positive emotion in cocaine addiction, and tests a medication that may restore positive emotional functioning and help people quit.

Selected Grants

National Institute on Drug Abuse, Targeting Anhedonia in Cocaine Use Disorder, PI

Selected Publications

Suchting, R., Vincent, J.N., Lane, S.D., Green, C.E., Schmitz, J.M. & Wardle, M.C. (2019) Using a data science approach to predict cocaine use frequency from depressive symptoms. Drug and Alcohol Dependence, 194, 310-217. PMC6317336

Fries, G.R., Khan, S., Stamatovich, S., Dyukova, E., Walss-Bass, C., Lane, S.D., Schmitz, J.M. & Wardle, M.C. (2018) Anhedonia in cocaine use disorder is associated with inflammatory gene expression. PLoS One, 13, e0207231. PMC6224118

Wardle, M.C., Lopez-Gamundi, P.* & LaVoy, E.C. (2018). Effects of an acute bout of physical exercise on reward functioning in healthy adults. Physiology and Behavior, 194, 552-559. PMC6086604

Wardle, M.C., Lopez-Gamundi, P.*, & Flagel, S.B. (2018). Measuring appetitive conditioned responses in humans. Physiology and Behavior, 188, 140-150. PMC5845787

Wardle, M.C., Vincent, J.N., Suchting, R., Green, C.E., Lane, S.D. & Schmitz, J.M. (2017) Anhedonia is associated with poorer outcomes in contingency management for Cocaine Use Disorder. Journal of Substance Abuse Treatment, 72, 32-29. PMC5154907

Wardle, M.C., & de Wit, H. (2012). Effects of amphetamine on reactivity to emotional stimuli. Psychopharmacology, 220, 143-153. PMC3277682

Wardle, M.C., Treadway, M.T., Mayo, L.M., Zald, D.H. & de Wit, H. (2011). Amping up effort: Effects of d-amphetamine on human effort-based decision-making. Journal of Neuroscience, 31, 16597-16602. PMC3234999

Education

B.H.A. in Psychology and Art, 2001, Carnegie Mellon University
Ph.D. in Clinical Psychology, 2009, University of Illinois at Chicago
Postdoctoral Fellow in Human Behavioral Pharmacology, 2009 – 2012, University of Chicago

Licensures and Certifications

Licensed Clinical Psychologist, Illinois, September 2015 – present